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Tic cancer, there is considerable heterogeneity in the molecular make-up, MAPK/ERK pathway activation states, and clinical outcome in this disease. We analyzed the expression levels of CNKSR1, a scaffold that influences MAPK/ ERK pathway activity, in clinical pancreas cancer specimens and their impact on survival of patients with pancreatic cancer. Methods: Immunohistochemical staining for CNKSR1
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Verges to a 0.5 ?interface rmsd structure relative to the previously reported NMR ensemble (Figure 5C and E). The converged low-energy structures resulting from this protocol (Figure 5E) are consistently lower in energy than theARTICLEpartially unfolded dimers obtained with symmetric docking (Figure 5D), providing further indication that the structure is interleaved. We have further tested this a
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